The User...

...doesn't care about the cleverness of your design. He doesn't care if you use "they" or "he" as a generic pronoun - but saying "he/she" or "(s)he" will create a speedbump in his movement through your content. Users want to get what they came for - whether it's information, education, training, or entertainment. Unless it's easy fro them to get - to "use," - they're going to move on.